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Ambify reddit4/27/2023 ![]() Accordingly, part of its methodology on quality of evidence is based on quantity of qualified studies. A Cochrane review found only low quality evidence of effectiveness in treating schizophrenia. A 2011 Cochrane review comparing aripiprazole with placebo concluded that high dropout rates in clinical trials, and a lack of outcome data regarding general functioning, behavior, mortality, economic outcomes, or cognitive functioning make it difficult to definitively conclude that aripiprazole is useful for the prevention of relapse. Ī 2014 Cochrane review comparing aripiprazole and other atypical antipsychotics found that it is difficult to determine differences as data quality is poor. A 2014 NICE review of the depot formulation of the drug found that it might have a role in treatment as an alternative to other depot formulations of second generation antipsychotics for people who have trouble taking medication as directed or who prefer it. The 2016 NICE guidance for treating psychosis and schizophrenia in children and young people recommended aripiprazole as a second line treatment after risperidone for people between 15 and 17 who are having an acute exacerbation or recurrence of psychosis or schizophrenia. Medical uses Īripiprazole is primarily used for the treatment of schizophrenia or bipolar disorder. In 2020, it was the 89th most commonly prescribed medication in the United States, with more than 8 million prescriptions. Īripiprazole was approved for medical use in the United States in 2002. It has not been very well studied in people less than 18 years old. It is not recommended in women who are breastfeeding. In pregnancy, there is evidence of possible harm to the baby. It is not recommended for older people with dementia-related psychosis due to an increased risk of death. Serious side effects may include neuroleptic malignant syndrome, tardive dyskinesia and anaphylaxis. Ĭommon side effects include vomiting, constipation, sleepiness, dizziness, weight gain and movement disorders. ![]() Side effects in children are similar, and include sleepiness, increased appetite, and stuffy nose. In adults, side effects with greater than 10% incidence include weight gain, headache, akathisia, insomnia, and gastro-intestinal effects like nausea and constipation, and lightheadedness. A Cochrane review found low-quality evidence of effectiveness in treating schizophrenia. It is taken by mouth or injection into a muscle. Other uses include as an add-on treatment in major depressive disorder, tic disorders and irritability associated with autism. It is primarily used in the treatment of schizophrenia and bipolar disorder. Aripiprazole, sold under the brand names Abilify and Aristada among others, is an atypical antipsychotic.
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